Lycopene modulates several of the aforementioned pathways, providing a promising rationale for prostate cancer risk reduction by lycopene: In many experimental setups, lycopene reduced inflammatory signals, prevented oxidative DNA damage, modulated the expression or activity of IGF axis members, of Wnt/beta-catenin and androgen signalling, and enhanced gap junctional communication. Without a doubt, tomatoes have the highest content of lycopene among all fruits and vegetables. When they are overactive, cells start dividing excessively, and cancer ensues. Ben Ong and Total Health are trademarks of FYRTORR LTD. and cannot be used without Lycopene's influence on these pathways likely contributes to the observed cell growth inhibition and apoptosis induction by lycopene. Prostate cancer is a very common cancer among men. Save my name, email, and website in this browser for the next time I comment. Whole foods that are rich in lycopene are highly nutritious and rich in other vitamins and dietary fiber. Lycopene has been studied in basic and clinical research for its potential effects on cardiovascular diseases and prostate cancer, although as of 2017 there is no good evidence of benefit in prostate … In all of these fruits, lycopene contributes to the red color and appearance of foods. According to a study published in The Journal of Nutrition After analyzing the effects of lycopene on healthy human prostate cells, the authors found that this carotenoid acts on the cell cycle of healthy prostatic cells. Get the latest public health information from CDC:, Get the latest research information from NIH:, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: It is likely that lycopene from whole foods exerts health benefits … the age of 50, suggests a new study from Germany. Tomato intake providing about 30 mg of lycopene reduces PSA in men with prostate cancer (Chen, 2001; Paur, 2017). Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells. The final reason is price. Diet, Nutrition, Physical Activity and Prostate Cancer. Improvement of inflammation in and around the tumor, which reduces the available nutrients for cancer to keep growing. 2001 Aug;10(8):861-8. It also modulates the division and growth of prostatic tissue. Prostate cancer (PCa) is a common illness for aging males. Lycopene consumption from dietary sources seemed to have a bigger impact on heart disease risk than supplements, one study found (Burton-Freeman, 2014). 75 (1), p54-60. Researchers linked high lycopene intakes to a 9% lower likelihood of developing prostate cancer. It may also protect against cancers of the lungs, breasts and … Carotenoid absorption from salad and salsa by humans is enhanced by the addition of avocado or avocado oil. Early research suggests that lycopene may slow prostate enlargement in people with benign prostatic hypertrophy (BPH). for good", UK Tel:+44 (0) 845 The Journal of nutrition, 133(11), 3356-3360. Would you like email updates of new search results? However, more high-quality studies are needed in this area. As an added benefit, lycopene also has anti inflammatory effect on the blood vessels inside the brain, which acts as a protection against stroke. The second line of evidence for the benefit of tomatoes is based on laboratory studies, on lab-grown cells and in animals. In short, we can describe two main mechanisms behind the potential of lycopene to slow down cell proliferation. A large jar of organic, sun-dried tomatoes in olive oil will cost you about $10-12. They are triggered whenever the prostate increases its size. According to, most clinical studies have focused on the amount of lycopene-containing foods that participants ate rather than on the specific quantities of lycopene they consumed. The role of lycopene may also contribute to the prevention of prostate cancer because of the same and other added mechanisms (3). Karppi, Jouni, et al. Enhanced cytotoxic and apoptosis inducing activity of lycopene oxidation products in different cancer cell lines. How does Lycopene affect prostate cancer? It is thought to do so by clearing the body of prostate cancer cells and other cancer cell lines in a natural way (3). Are there adverse effects of lycopene exposure?. Arch Biochem Biophys. Lycopene modulates several of the aforementioned pathways, providing a promising rationale for prostate cancer risk reduction by lycopene: In many experimental setups, lycopene reduced inflammatory signals, prevented oxidative DNA damage, modulated the expression or activity of IGF axis members, of Wnt/beta-catenin and androgen signalling, and enhanced gap junctional communication. Sferrazza G, Corti M, Brusotti G, Pierimarchi P, Temporini C, Serafino A, Calleri E. Acta Pharm Sin B. However, a recent review of 26 studies found more moderate results. “Role of antioxidant lycopene in cancer and heart disease.” Journal of the American College of Nutrition 19.5 (2000): 563-569. In this article, we will be discussing what lycopene is, the health benefits it offers, and the best sources of lycopene it to your diet. Lycopene is a fat-soluble nutrient and is only well absorbed by the body when you consume it along with some dietary fat lycopene. The prostate response to prolactin modulation in adult castrated rats subjected to testosterone replacement. Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema.. International Journal for Vitamin and Nutrition Research. Lycopene inhibits the growth of normal human prostate epithelial cells in vitro. Cancer is one of the reasons why the tissue of the prostate may grow large enough to become an obstruction of the urinary tract, but it is not the only one. This is a normal function of almost every cell line and allows them to regenerate damaged tissue. Trumbo, P. R. (2005). It may be the most abundant nutrient of the carotenoid family related to prostate health [Source: Borek]. *DISCLAIMER: PLEASE NOTE THAT THIS WEBPAGE IS NOT INTENDED TO BE MEDICAL ADVICE. As a result, it turns a normal function into a severe disease in the prostate or any other tissue. Lycopene and bone: an in vitro investigation and a pilot prospective clinical study. All of these changes block the groundwork that is required for cell division and freezes cancer cells into a phase of the cell cycle (9). Similarly, a recent review of clinical trials has recently shown how common it is to have natural products and foods as a source of cancer-fighting molecules (2). International journal of molecular sciences, 14(7), 14620-14646.  |  Like many other types of cancer, prostate cancer is influenced by genetics. Transcription factors are activated, new genes are made available, and new proteins are assembled. Other benefits of Lycopene As well as demonstrating benefits for prostate health, lycopene has also been linked to other health benefits including Antioxidant properties – Lycopene is an antioxidant in the carotenoid family. Please enable it to take advantage of the complete set of features! When the subjects consumed 8-16mg of the supplement for 12 weeks, the group suffered less severe skin reactions. However, there are various sources to choose from. Lycopene has been shown to reduce the risks of certain cancers. Lycopene, a member … Lycopene Supplements Beneficial in Prostate, Heart, and Cancer Diseases. This substance is rich in foods like tomato, and it gives its vivid color. J Soc Integr Oncol. Enhanced bioavailability of lycopene when consumed as cis-isomers from tangerine compared to red tomato juice, a randomized, cross-over clinical trial. Further studies have demonstrated higher fruit and vegetable intake, which in turn increases lycopene intake, helps lower prostate cancer risk [Source: Smith-Warner]. SHOULD ALWAYS CONSULT YOUR MEDICAL PROFESSIONAL. 2020 Jan 29;18(1):43. doi: 10.1186/s12967-020-02238-7. That includes cyclins, transcription factor E2F, and many other enzymes. Lycopene’s main health benefit is its antioxidant function. NCI CPTC Antibody Characterization Program. Kaiser A, Haskins C, Siddiqui MM, Hussain A, D'Adamo C. Curr Opin Oncol. One of the mechanisms that explain why lycopene improves the clinical condition of patients with prostate cancer is that this molecule induces apoptosis in growing tumors. 2004 Oct 1;430(1):127-34. doi: 10.1016/ NIH Pumpkin Seed Pumpkin seeds are a healthy source of fibre, beneficial fats, antioxidants and minerals, and a rich source of zinc, an important but poorly-understood agent for prostate health ⁽²¹⁾ . Similar to Pygeum, Lycopene too inhibits androgen receptors inside the prostate. Lycopene is a constituent of human redox defence mechanism against free radicals. Lycopene health benefits include treating neurological disorder, preventing stroke, supporting immune system, preventing macular degeneration, alleviating osteoporosis, fighting diabetes, treating prostate cancer, controlling cholesterol level, treating infertility, and promoting hair growth. Aust O1, Stahl W, Sies H, Tronnier H, Heinrich U.. (2005). Drinking antioxidant-rich green tea invites a host of potential dietary benefits beyond prostate health, but if caffeine exacerbates your BPH symptoms, it’s best avoided. Lycopene has been shown to induce apoptosis in cancer cells. Whether lycopene itself or its metabolites induce most of its benefits is still uncertain. These include watermelon, guava, apricot, pink grapefruit, and rosehips. Unlu, NZ; et al., lycopene from heat-induced cis-isomer-rich tomato sauce is more bioavailable than from all-trans-rich tomato sauce in human subjects. It is a rather complex topic, but after short minutes of reading, you will understand what it’s all about. Recent studies have suggested that lycopene, a powerful antioxidant, could have impressive benefits for prostate health. YOU Home » How Does Lycopene Help The Prostate? If you want to consume more lycopene in your diet, chop and cook tomatoes instead of eating them fresh, this will contribute to the absorption of lycopene. It is associated with impressive benefits for patients with prostate cancer. Lycopene may show benefits against benign prostate hyperplasia. Early research shows that taking lycopene can slow the rate of prostate growth and can improve symptoms in people with this condition. Some research shows lycopene may be help to prevent heart disease, atherosclerosis, prostate and breast cancers. Antioxidants protect the body from free radicals, which can result in oxidative stress. Cell cycle arrest: Cell proliferation requires preparation by the dividing cell. World Cancer Research Fund International. Tomatoes contain a powerful antioxidant called lycopene.It may help prostate cancer as well as reduce tumor growth among men with prostate preventcancer. At present, meta-analysis of clinical studies of lycopene for prevention of prostate cancer in men does not yet support the definitive clinical use of this carotenoid in a preventive setting. ©2013 AACR . Written By Dr Alberto Parra on October 31, 2019, Contents What is vitamin E What are the types of vitamin E? 2017 Dec;48(5-6):403-415. doi: 10.1007/s10735-017-9738-z. The potential role of lycopene for the prevention and therapy of prostate cancer: from molecular mechanisms to clinical evidence. A recent study showed that 10 servings of tomato every week is associated with a reduced risk of prostate cancer by 20% in the United Kingdom. Several signaling pathways have been identified as players in prostate cancer development. Fiedor J, Burda K. Potential role of carotenoids as antioxidants in human health and disease. For prevention, a higher intake of lycopene shows greater benefit [Source: Giovannucci]. However, prostate cancer risk is modulated by different factors. It is found in intensive concentrations in the testes and seminal plasma and decreased levels have been demonstrated in me… Lycopene reduced gene expression of steroid targets and inflammatory markers in normal rat prostate. The Journal of Nutrition . According to the National Cancer Institute, cell proliferation refers to an increase in cell number that results from cellular growth and division. Thus, it is capable of helping the body to destroy cancer cells. Some studies have suggested that lycopene may be beneficial for patients recovering from this disease. J Mol Histol. A couple of studies endorse the lycopene benefits for men through a series of human trials. Lycopene shows antioxidant and anticancer properties. Regular consumption of lycopene-rich foods has been reported to be associated with a 30 to 40% lower risk of prostate cancer (3,4), and lycopene rather than other carotenoids is inversely correlated to risk of prostate cancer (3,5–7). Enlarged prostate (benign prostatic hyperplasia or BPH). This site needs JavaScript to work properly. Lycopene is a provitamin A carotenoid that is responsible for the pink and red colors that we see in grapefruit, tomatoes, red peppers, and purple cabbage. Sesso HD1, Liu S, Gaziano JM, Buring JE.. (2003). Lycopene health benefits have been shown to include the prevention of a wide variety of cancers, including prostate, lung, colon, cervical and breast cancer. (2013). Studies have found that Lycopene can protect your DNA, your prostate health, your skin and your bones. As shown in various studies, lycopene is capable of clearing the blood out of an insulin-like growth factor and inhibit the action of many others by blocking their signaling pathways (11). Constantino FB, Camargo ACL, Santos SAA, Colombelli KT, Martin LF, Silva MG, Felisbino SL, Justulin LA. HHS Lycopene supplementation may also not offer the same health benefits as a robust dietary intake. Cooperstone, JL; et al. Regularization of the cell cycle, which is altered and uncontrolled in cancer. Herzog A, Siler U, Spitzer V, Seifert N, Denelavas A, Hunziker PB, Hunziker W, Goralczyk R, Wertz K. FASEB J. There are four reasons for this: Lycopene is a powerful antioxidant that has been shown to offer significant benefits for prostate health. Trejo-Solís, C., Pedraza-Chaverrí, J., Torres-Ramos, M., Jiménez-Farfán, D., Cruz Salgado, A., Serrano-García, N., … & Sotelo, J. The most well-publicized of all the lycopene health benefits may be its role in preventing prostate cancer. The antioxidant properties help balance free radical activity in the body and in doing so, may offer protection against certain diseases, keep bones strong and healthy, and help eyesight by helping delay or prevent cataracts, macular degeneration, and other age-rel… Rao, A. Venket, and Sanjiv Agarwal. Further research is needed to confirm a benefit, but in one review of 11 studies, researchers found a trend suggesting that men who ate more tomatoes and tomato-based products, both raw and cooked, may be less likely to develop prostate cancer. Prostate health is related to lifestyle and diet (1). However, oxidative damage in the DNA of prostate epithelial cells or any other cell line predisposes to the formation of prostate cancer cells. These cells display an exaggerated replication that creates a tumor. Benefits of Lycopene in Cancer. Lycopene is a powerful antioxidant carotenoid which is the source of the red coloring of tomatoes. Lycopene is a carotenoid. Antioxidants are molecules that fight free radicals in our bodies. Lycopene is a carotenoid, a molecule that is similar to that of vitamin A. They are: As well as demonstrating benefits for prostate health, lycopene has also been linked to other health benefits including. This is very effective if we’re talking about a natural product that is affordable and easy to incorporate in your diet. Lycopene: modes of action to promote prostate health. Regulation of growth factors: There are chemicals in the body that serve as signals or red flags that promote cellular growth and proliferation. Instead, they replicate without any control. The evolving role of diet in prostate cancer risk and progression. Lycopene, a red carotenoid consumed primarily from tomatoes and a few other plant-based foods, is one of the most promising chemopreventive agents found in Western diets (2). A red pigment, lycopene is commonly found in fruits and vegetables of that hue. Holzapfel, N., Holzapfel, B., Champ, S., Feldthusen, J., Clements, J., & Hutmacher, D. (2013). However, it is important to note that when choosing a source of lycopene, whole foods are the best option. What causes BPH? Lycopene has been suggested to be beneficial for some eye disorders. It is embedded in the natural program of the DNA to destroy any cell that is not functional or has become dangerous. Other benefits of Lycopene include  |  We all know that vitamin A is fundamental for an excellent vision, but not all of us know it is also an outstanding antioxidant. Read about the history of research, laboratory, and human studies on various prostate supplements, such as calcium, green tea, lycopene, pomegranate, selenium, soy, and vitamin E in this expert-reviewed summary. Evidence-based complementary and alternative medicine, 2013. Click & discover the wonderful benefits of Lycopene > The most common cause of LUTS in men is benign prostatic hyperplasia (BPH). Lycopene also contains lipid antioxidant properties that aid in prostate health. They have different functions depending on their structure. Lycopene supplements and tomato-based products that contain lycopene are safe and well-tolerated. A substantial part of the lycopene effects can be explained by its antioxidant action, but other mechanisms might also be involved. Molecular Nutrition and Food Research, 2015; 59(4): p. 658-69. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 12(1), 49-75. Epub 2017 Oct 7. Risk Factors Complications of BPH Can diet help […], Contents What is an enlarged prostate Symptoms of an enlarged prostate Causes of an enlarged […], "We thank you for your support in our united mission to end prostate disease Epidemiological evidence links lycopene consumption with decreased prostate cancer risk. 10 servings of tomato are equal to 10 cups of chopped tomatoes. Chronic prostatitis, for example, due to infections, is a suggested risk factor for prostate cancer. Also found in cell membranes and plays an effective role in maintaining the cell’s integrity when it is under assault by toxins. doi: 10.1111/cpr.12299. This country has 35,000 new cases of prostate cancer every year, and 10,000 prostate cancer patients die as a result of complications or metastasis (6). Thus, a good supplement for your prostate does not only fight prostate cancer but also slows down the growth of this vital gland. During disease progression, and after androgen ablation therapy, the remaining operational pathways are upregulated to compensate for the lost growth signal, finally resulting in androgen-independent prostate cancer. Cancer Prev Res; 6(5); 384–6. Thus, colorful and red tomatoes are likely to have more lycopene. Secondly, the shape of lycopene molecules can either be CIS-lycopene (Bent) or TRANS-lycopene (Straight). Lycopene is one of the most potent natural antioxidants. British Journal of Nutrition, 2007; 98: p. 140–146. 2014;6(2):466–488. Scientific literature documents lycopene’s antioxidant activity and its use in cancer prevention (breast and prostate), as well as its use in the prevention of cardiovascular disease. “Serum lycopene decreases the risk of stroke in men: a population-based follow-up study.” Neurology 79.15 (2012): 1540-1547. Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. However, there is not enough evidence to say that lycopene provides such health benefits. This indicates that lycopene may prevent the spreading of cancer. It can definitely stop the enlargement of the prostate … 2008 Winter;6(1):29-36. COVID-19 is an emerging, rapidly evolving situation. Apoptosis is a natural process of programmed cell death. Farahmand L, Darvishi B, Majidzadeh-A K, Madjid Ansari A. November 2014. (BPH), a condition said to affect more than half of all men over. These include oxidative stress and changes in the prostate tissue. 2005 Feb;19(2):272-4. doi: 10.1096/fj.04-1905fje. Obermüller-Jevic, U. C., Olano-Martin, E., Corbacho, A. M., Eiserich, J. P., Van der Vliet, A., Valacchi, G., … & Packer, L. (2003). Multiple molecular and cellular mechanisms of action of lycopene in cancer inhibition. The Journal of nutrition, 135(8), 2060S-2061S. There are several published studies that evaluate whether lycopene in tomato products or supplements could have protective effects against prostate cancer and cardiovascular disease. Lycopene is a natural product that has recently gained attention as an agent for prostate cancer prevention and treatment. A significant reduction of the oxidative stress inside the cell. According to a review of the scientific literature, these anti-cancer mechanisms may be involved in helping prostate cancer recovery: Increasing your daily intake of lycopene through the consumption of cooked tomatoes could be beneficial for prostate health. Lycopene has been studied for the prevention of prostate cancer, with mixed results. 2019 May;31(3):222-229. doi: 10.1097/CCO.0000000000000519. 2020 Oct;10(10):1814-1834. doi: 10.1016/j.apsb.2019.12.019. permission © 2008-2021 Arathi, B. P., Sowmya, P. R. R., Kuriakose, G. C., Vijay, K., Baskaran, V., Jayabaskaran, C., & Lakshminarayana, R. (2016). This plant-derived compound is not essential for humans but its health benefits are many. The baseline plasma lycopene level of cases was compared with that of age-matched prostate cancer-free controls. By preventing these receptors, Lycopene can stop cells from growing, effectively minimizing prostate growth. The only adverse effects so far are gastrointestinal problems (diarrhea, gas, nausea, and vomiting) that may appear in some people (7). 2000;36(1):101-11. doi: 10.1207/S15327914NC3601_14. It also helps to maintain a healthy function by exchanging old and non-functioning cells with new ones (8). Lycopene in the prevention of prostate cancer. Nutrients. NLM Mondal, S., Bandyopadhyay, S., K Ghosh, M., Mukhopadhyay, S., Roy, S., & Mandal, C. (2012). Natural products: promising resources for cancer drug discovery. Some studies show how certain nutrients may protect men against this type of cancer. Clipboard, Search History, and several other advanced features are temporarily unavailable. Forty people took part in the new pilot study, which adds clinical data to an area previously lacking, according to the researchers in this month's Journal of Nutrition. Still, in these cases, there’s no hepatic dysfunction after using very high doses. Published 2014 Jan 27. doi:10.3390/nu602046. Epub 2016 Sep 27. Russo C, Ferro Y, Maurotti S, Salvati MA, Mazza E, Pujia R, Terracciano R, Maggisano G, Mare R, Giannini S, Romeo S, Pujia A, Montalcini T. J Transl Med. If you don’t tolerate tomatoes, consider getting a supplement with at least 10 mg of lycopene per capsule. The next reason to get lycopene from your diet instead of supplements is that supplements will contain much smaller doses than what you can get from just a small amount of food. Lycopene may also affect the insulin-like growth factor (IGF) intracellular pathway in prostate cancer cells. Diets rich in the antioxidant lycopene may help prevent the development of prostate cancer. Thus, lycopene is proposed as a potential preventative measure to reduce the risk of enlargement in healthy cells. One of the ways that Prostate health is measured by the incidence of lower urinary tract symptoms (LUTS) in men. However, similar to carrots, consumption of excessive doses are associated with lycopenemia. Unlu, NZ; Bohn, T; Clinton, SK; Schwartz, SJ.  |  This is an abnormal growth of the human prostate that is not necessarily malignant. Also, try other colored fruits like papaya, and don’t think tomato products are deprived of lycopene. Epub 2020 Jan 7. Nutrition methods and dietary supplements have been studied for prostate cancer prevention or treatment. For example, boron is a trace element that is known to improve prostate health (1). Among the different benefits that lycopene has to offer, one of the most interesting to understand is how it modulates cell proliferation. Lycopene did not interfere with normal prostate growth but seemed to modulate the expression of genes crucial to prostate health. Lycopene is known to reduce the phosphorylation and activation of enzymes. This type of cancer is heightened or fueled by testosterone and other male sex hormones which is why the therapy for prostate cancer involves lowering the hormone level in … It may also prevent the progression of the disease in cases of active benign prostatic hyperplasia (4). Lycopene has been identified as an antioxidant agent with potential anticancer properties. Androgen signaling, cytokine (IL-6, IL-4) and growth factor signaling (e.g., IGF, Wnt/beta-catenin) cross-talk via PI3K/Akt, MAPK, and Jak/STAT pathways have been identified as major controllers of prostate growth. These benefits were exerted from lycopene from whole foods rather than as an extract. A lower risk of prostate cancer, particularly for aggressive prostate cancer (RR = 0.56; 95% CI = 0.34–0.92) was found when comparing high with low quintile of plasma lycopene. Although lycopene may offer numerous health benefits, a recommended intake for this plant pigment has not been established. However, it is important to note that when choosing a source of lycopene, whole foods are the best option.