The antioxidant properties help balance free radical activity in the body and in doing so, may offer protection against certain diseases, keep bones strong and healthy, and help eyesight by helping delay or prevent cataracts, macular degeneration, and other age-rela… This leads to conditions such as cancer, heart disease, macular degeneration, diabetes, joint deterioration and accelerated aging. Adult male rats were divided into four (vehicle control, lycopene, PCBs and PCBs+lycopene treated) groups. Gac fruit contains 70 times as much lycopene as tomatoes, which are one of the primary sources of lycopene in the American diet. The age ranged from 32-45 years old (mean 34.5). Durairajanayagam D, Agarwal A, Ong C, Prashast P. Lycopene and male infertility. Lycopene is found in tomatoes, watermelons, red oranges, pink grapefruits, apricots, rosehips, and guavas. Lycopene, as an antioxidant, reduces oxidative stress. Lycopene inhibits free radical damage to LDL cholesterol with its antioxidant action preventing oxidation to LDL cholesterol. Semen analysis was done in the third month after operation and 4 of 7 (57%) showed improvement of semen analysis but another 3 cases (43%) still had azoospermia. Men with a good percentage of high-quality, undamaged sperm are more likely to impregnate a partner. on the effects of lycopene on sperm count and quality, researchers found that consuming 14mg of lycopene per day can actually greatly benefit sperm production! Lycopene - Role in male fertility• Bright red carotenoid pigment, phytochemical and powerful antioxidant with a major role in the management of idiopathic male infertility. The recent research for new anticancer drugs focuses on natural compounds from the regular human diet because these compounds rarely exhibit severe side effects yet efficiently act on a wide range of molecular targets involved in carcinogenesis. “Oxidative stress may play a role in male infertility pathogenesis and while reactive oxygen species play a role in normal sperm function, disequilibrium of reactive oxygen species and antioxidant defence appears to be detrimental. With all these amazing properties of lycopene, you’re probably wondering where exactly gac fruit fits into this picture. Symptoms of menopause. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. Background and objectives: This study aimed to investigate the effects of tomato juice consumption on seminal plasma lycopene levels and sperm parameters in infertile men. Hence, there is a need to increase the dietary intake of an effective antioxidant such as lycopene. Maximum improvement seems tooccur in the sperm concentration (66% cases).Patients without severe oligospermia (spermdensity >5 million/ml) may be given a trialof therapy with lycopene. Lifestyle Lycopene: Male fertility could be improved by nutrient found in tomato puree Eating tomato puree could be beneficial in improving male fertility, a new study has suggested. In young men, taking the recommended dose of lycopene increased sperm mobility and healthy shaped sperm by 40%. Lycopene is a carotenoid found in foods such as tomatoes, tomato products, watermelon, pink grapefruit and guava. It has been suggested that oxidative damage may negatively affect sperm. Fertility experts said more studies were needed involving men known to have fertility problems. A unique view on male infertility around the globe. Free full text Asian J Androl . Therapeutic dosage of lycopene range from 6-60 mg daily. Lycopene is a carotenoid and antioxidant that is found in several different kinds of vegetables. While sunburns aren’t exclusive to men, men are statistically more likely to develop melanoma. In fact, just a few of the additional benefits of that size serving of lycopene include: GacLife’s benefits don’t stop with the beverages, either. View abstract. In today’s world, it’s tougher than ever to stay healthy, fight disease, and keep our bodies in tip-top shape. Infertility affects up to 15% of the population globally , and furthermore, male infertility is responsible in about 20% of cases but may contribute to 40% of infertile couples . All the men were given 2000 micrograms of lycopene, twice a day for three months. Impact of lycopene on epididymal androgen and estrogen receptors' expression in polychlorinated biphenyls-exposed rat. The good news is that there’s a way to combat these issues! Because lycopene is an antioxidant, it has certain properties that help it fight against something called “free radical compounds”. That makes this antioxidant a fantastic, healthy way of reducing cancer risk and staying healthy! That’s where lycopene comes in again. In young men, taking the recommended dose of lycopene increased sperm mobility and healthy shaped sperm by 40%. Transurethral resection of ejaculatory duct (TURED) was done in 6 cases and transurethral incision of ejaculatory duct (TUIED) was done in 1 case. Human trials have reported sperm parameter improvement and pregnancy rates with supplementation of 4–8 mg of lycopene daily for 3–12 months. Up to one year, 6 of 7 (86%) have normal semen analysis and another one still had azoospermia. Excessive amounts of reactive oxygen species (ROS) cause a state of oxidative stress, which result in sperm membrane lipid peroxidation, DNA damage and apoptosis, leading to decreased sperm viability and motility. This discovery could drastically renew couples’ outlook on their ability to conceive who have been struggling due to male factor infertility. Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene daily for 3-12 months. Our laboratory has postulated that metabolic products of lycopene, the lycopenoids, may be responsible for some of lycopene’s reported bioactivity. Each teaspoon of gac powder contains 8.8mg of lycopene, which makes it another great way of incorporating this antioxidant into your diet. 5. Normal testicles and secondary sex characteristics were noted in all. One of the biggest benefits of lycopene is that it is an antioxidant and protects the body of damage from free radical stress, which can hurt DNA and other cell structures. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene for male infertility treatment . Excessive generation of reactive oxygen species (ROS) containing free oxygen radicals has been iden-tiﬁed as one of the causes of male infertility. Lycopene: a naturally synthesised carotenoid present in fruits and vegetables. Raj MV, Selvakumar K, Krishnamoorthy G, Revathy S, Elumalai P, et al. Its use in the treatment of male infertility is based on its free radical scavenging abilities. Increasing evidence suggests that environmental pollutants including polychlorinated biphenyls (PCBs) are male infertility, which is associated with oxidative stress. According to MayoClinic.com, recommended doses of lycopene generally range from 2 to 30 mg per day for up to six months. Currently, there is no official recommended amount for daily intake of lycopene. Which brand of lycopene is best? Let’s break it down. For Positive Outcome in Treatment of Male Infertility. The appropriate dose and duration of lycopene supplementation remains to be determined. In the long-term follow-up, 4 of 7 (57%) were able to impregnate their wives. Six months after operation 6 of 7 (86%) showed improvement of semen analysis. Evidence-based medical therapy for male infertility is an attractive research area where a large number of clinical trials, controlled and uncontrolled, using different types of medications have been conducted yielding variable results and outcomes. In this randomized, double-blind, placebo-controlled trial study, 44 infertile men with oligozoospermia were randomly divided into two groups: The experimental group was supplemented with 25 mg of lycopene, … Conditions in a man that prevent him from getting a woman pregnant within a year of trying to conceive (male infertility). Lycopene administered as a pure compound has been studied in clinical trials at dosages of 8 to 75 mg/day.66, 80, 81, 82, 83, 84 Lycopene is primarily available in capsule and softgel form, with dosage guidelines from manufacturers ranging from 10 to 30 mg taken twice daily with meals. For couples struggling with infertility, this is a huge discovery; almost 50% of infertility cases are caused by male sperm health issues. Introduction: That’s right, and the numbers are pretty scary; heart disease takes over 300,000 men’s lives per year. It is a non-toxic and is commonly found in the diet. … A variety of epidemiological trials have suggested that higher intake of lycopene-containing foods (primarily tomato products) or blood lycopene concentrations are associated with decreased cardiovascular disease and prostate cancer risk. In particular, men’s health issues are becoming more and more prevalent. In a recent study on the effects of lycopene on sperm count and quality, researchers found that consuming 14mg of lycopene per day can actually greatly benefit sperm production! However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility. The success rate is not associated with the number of sperm abnormalities in our study. Men are struggling with fertility issues, low sperm count, and prostate cancer, which can all be devastating for those involved, especially when trying to build a family. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility. Conditions in a man that prevent him from getting a woman pregnant within a year of trying to conceive (male infertility). C. Infertility. “The antioxidant properties of lycopene have been the focus of lycopene’s action on male infertility to date,” the team say. The top sources for lycopene include: Whichever food source you choose, getting a healthy dose of lycopene is the first step in taking care of your health! After the experimental period (30days), the animals were decapitated for the blood collection and testes were removed for the isolation of Sertoli cells. Asian Journal of Andrology (2014) 16, 420–425; doi: 10.4103/1008-682X.126384; published online: 18 March 2014 In conclusion, the presence of lycopene in the extender improved the survival of turkey spermatozoa after liquid-storage and protected DNA integrity against cryodamage. However, most studies done in this regard are observational . Seventy-one per cent had normal hormonal profiles and twenty-nine per cent had a slight increase of FSH, LH but not more than one fold of normal range. pregnancy rate per cycle is obtained with 5.10(6) to 10.10(6) inseminated. Lycopene improves sperm concentration and motility. HCG: 500 to 1000 units IM 3 times a week for 3 weeks, then 500 to 1000 units IM 2 times a week for 3 weeks OR 4000 units IM 3 times a week for 6 to 9 months, then 2000 units IM 3 times a week for 3 months Uses:-Selected cases of hypogonadotropic hypogonadism in males Lycopene is believed to have antioxidant benefits and has been studied for use in infertility. Asian J Androl 2014. doi: 10.4103/1008-682X.126384. Additionally, its quality of reducing harmful “free radical” compounds also makes it a great way to combat heart disease. But how does that work? ConsumerLab's tests revealed that one product contained only 60% of its listed lycopene; pills strengths ranged from 5 mg to 30 mg; and the cost to get a 10 mg dose of lycopene ranged from just 7 cents to 53 cents. L- Carnitine plays important role in the formation of sperm. The findings point out that lycopene protects the Sertoli cell function by preventing PCBs-induced oxidative stress and endocrine disruption. By age 80, men are 3 times as likely as women are to develop melanoma. Multiple over‐the‐counter (OTC) therapies have been historically used for male fertility, including herbs, vitamins, and nutritional supplements (Crimmel et al, 2001).Because infertility affects 15% of couples trying to conceive, with male factor implicated solely or in combination with a female factor in 50% of the cases, many male patients use these therapies (Sharlip et al, 2002). Published 26 September 2019. Oligocare provides a unique combination of essential micronutrients and vitamins, to help support male fertility. Overview of ycopenel Lycopene is a red pigmented carotenoid naturally present in red colored fruits and vegetable sources, including tomatoes, watermelons, papayas, rosehips, pink grapefruits, apricots, and guavas. Sertoli cell functional proteins such as connexin 43, transferrin and androgen-binding protein expressions and the level of lactate were significantly decreased. Vegetables and fruits like red tomatoes, red fleshed watermelon, red guavas and red grapefruit are the good sources of lycopene. Male fertility problems. “The antioxidant properties of lycopene have been the focus of lycopene’s action on male infertility to date,” the team say. Background and objectives: This study aimed to investigate the effects of tomato juice consumption on seminal plasma lycopene levels and sperm parameters in infertile men. Lycopene was found to boost sperm count by as much as 70%. Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene daily for 3-12 months. The recommended daily intake of lycopene is 6 to 30 milligrams. Male factor infertility contributes partially and solely to the problem of childlessness in around 50% of the cases. Of the carotenoids tested, lycopene has been demonstrated to be the most potent in vitro antioxidant leading many researchers to conclude that the antioxidant properties of lycopene are responsible for disease prevention. Oral Lycopene therapy seemsto have a role in the management of idiopathicmale infertility. 3. Methods and study design: Subjects were male infertility patients with poor sperm concentration (<20×10 6/mL) and/or motility (<50%). And, it limits tumor growth in the prostate. According to researchers, taking 9-21mg of lycopene per day can help men reduce the risk of prostate cancer by 32-50%. And, what’s worse, Melanoma is the most prevalent form of skin cancer today. There is a huge need to advance and develop andrologic diagnostic techniques, focusing on the metabolomics and proteomics of the sperm, seminal plasma, and testicular tissue. It is found in high concentrations in the testes and seminal plasma and decreased levels have been demonstrated in men suffering from infertility. Free oxygen radicals are one of the important causes of male infertility, and antioxidant lycopene is known to get rid of these free radicals. Lycopene is a type of carotenoid, or plant-based pigment, that gives tomatoes, pink grapefruit and watermelon their red color. Blood samples were collected at the enrollment, end of 2 weeks of lycopene restricted diet and after 10 weeks of lycopene supplementation. “ A 2000 study in India examined 30 men with idiopathic infertility. … Are the health attributes of lycopene related to its antioxidant function? Usual Adult Dose for Hypogonadism - Male. Thus, the aim of this study was to evaluate the effect of lycopene supplementation on spermatogram and seminal oxidative stress. Ingestion by men of a combined dose of beta-carotene and lycopene does not affect the absorption of beta-carotene but improves that of lycopene. Expert opinion: The optimal dose of lycopene is not known. 2015. The aim of the present literature review was to investigate the most common antioxidants used for the treatment of male infertility and explore the doses that are associated with potential beneﬁt on basic semen parameter results, advanced sperm function tests, Except for one variable all the others failed to show a significant difference by statistical analysis between both treatments, however, the surgical treatment resulted in higher values when compared to the medical one. University of Massachusetts Medical School, Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported, Pengaruh Jus Tomat (Solanum lycopersicum L) terhadap Kualitas Sperma Mencit yang Diberi Paparan Asap Rokok Tersier, Biochemical and pharmacotherapeutic potentials of lycopene in drug discovery Preparation of Phytopharmaceuticals for the Management of Disorders, Biochemical and Pharmacotherapeutic Potentials of Lycopene in drug discovery, Biochemical and pharmaceutical potential of lycopene, Biochemical and pharmacotherapeutic potentials of lycopene in drug discovery, Lycopene antagonizes lead toxicity by reducing mitochondrial oxidative damage and mitochondria‐mediated apoptosis in cultured hippocampal neurons, Role of oxidative stress and antioxidant supplementation in Male fertility, Effect of D-Limonene on the Age-Related Androgenic Changes in Male Rats, Effect of lycopene supplementation on semen quality and reproductive performance in rabbit, Lycopene supplementation suppresses oxidative stress induced by a high fat diet in gerbils, Insight into oxidative stress in varicocele-associated male infertility: Part 1, Effects of lycopene on in vitro quality and lipid peroxidation in refrigerated and cryopreserved turkey spermatozoa. The spermograms of all the patients reported sperm counts, percentage of general motility, percentage of grade III motile sperm (rapid and directional movements) and percentage of oval forms, before and after the treatment. It is one of a number of pigments called carotenoids. Oral Lycopene therapy seemsto have a role in the management of idiopathicmale infertility. Early research shows that taking lycopene by mouth daily for 3 months improves sperm quality in some men with fertility problems due to unknown causes. After operation for subclinical varicocele, the spermiogram does not change, but a pregnancy rate of 30% is obtained. These results are analogous to those obtained in an operated group of clinical varicoceles. Lycopene is known to have antioxidant properties, meaning that it bonds with free radicals - neutralizing them. 1 mg/ml of lycopene were stored at 5°C for 48 h or cryopreserved as pellets and the following variables determined in fresh samples and samples stored chilled or frozen: sperm motility, viability, osmotic resistance, DNA integrity and lipid peroxidation (as malonaldehyde production). , which are one of the primary sources of lycopene in the American diet. All of the patients had azoospermia without other symptoms related to ejaculatory duct obstruction such as painful ejaculation, perineal or testicular pain. Menopausal symptoms. Lycopene and male infertility Damayanthi Durairajanayagam1,2, Ashok Agarwal 1, Chloe Ong , Pallavi Prashast Excessive amounts of reactive oxygen species (ROS) cause a state of oxidative stress, which result in sperm membrane lipid peroxidation, DNA damage and apoptosis, leading to decreased sperm viability and motility. An extensive literature search was performed using the search engines: Pubmed, Science-direct, Ovid and Scopus. While sunburns aren’t exclusive to men, men are statistically. The protective role of lycopene against various toxicants on various organs and its association with decreased oxidative stress seems to be well established. Besides anticancer activity, it is also beneficial in cardiovascular diseases, osteoporosis, bone health, male infertility, skin protection, age related macular degeneration prevention, Alzheimer's disease, amyotrophic lateral sclerosis, asthma caused by exercise, immune stimulation, viral disease and DNA damage. Ejaculatory duct obstruction is a treatable cause of male infertility. Semen quality was generally compromised after storage, especially post-freezing. Clarification of the causes of idiopathic male infertility and the discovery of novel molecular targets will help guide future innovative development of new pharmacologic agents. Lycopene therapy in idiopathic male infertility – a preliminary report Narmada P. Gupta & Rajeev Kumar Department of Urology, All India Institute of Medical Sciences, Ansari Nagar, 110029,New Delhi, India Abstract. Protective role of lycopene on polychlorinated biphenyls (Aroclor 1254)-induced adult rat Sertoli cell dysfunction by increased oxidative stress and endocrine disruption, Comparative analysis of lycopene in oxidative stress, Male infertility: A critical review of pharmacologic management, Sperm Diagnostics and Selecting Healthier Spermatozoa, Ejaculatory duct obstruction in the infertile male: Experience of 7 cases at Ramathibodi Hospital. Folic acid intake was associated with an elevation in reduced:oxidised glutathione ratio . Elevated levels of ROS are a major Many different types of medications have been tried and very few have had satisfactory results. This means they aren't able to conceive a child, even though they've had frequent, unprotected sexual intercourse for a year or longer. Simultaneously, lycopene induces enzymes of cellular antioxidant response element transcription system. Results of study revealed decreased lipid peroxidation and OS after various forms of lycopene supplementation but comparative analysis showed significant increase in OS biomarkers except MDA in patients receiving synthetic lycopene as compare to natural and placebo form. considerably in the dosage or combinations used, as well as outcome measures. medical treatment. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility. Average daily intake levels of lycopene range from 0.70 to 25.20 mg/day. The men would have needed to eat 2kg of cooked tomatoes each day to get the equivalent dose of lycopene. ConsumerLab's tests revealed that one product contained only 60% of its listed lycopene; pills strengths ranged from 5 mg to 30 mg; and the cost to get a 10 mg dose of lycopene ranged from just 7 cents to 53 cents. male infertility. Oligocare provides carefully balanced micronutrients and vitamins. In this study we investigated lycopene effects in an experimental model of varicocele. Hence, the present study was designed to find out whether PCBs disrupt Sertoli cell function by inducing oxidative stress or endocrine disruption? Male infertility affects up to half of couples who cannot conceive. International scientists, gathering to discuss the growing body of research on lycopene at a US conference this week, revealed a new study suggesting the antioxidant may help male infertility. All antioxidants have shown a role in destroying free radicals and thereby reducing the damage to all cells in the body. We conclude that there is an overall shortage of supportive evidence for the “antioxidant hypothesis” as lycopene’s major in vivo mechanism of action. The antioxidant properties of lycopene may help boost sperm quality. Numerous epidemiological studies have linked diets that are high in lycopene intake with a reduced risk of cancer and degenerative diseases. Whether lycopene attenuates PCBs-induced disruption in Sertoli cells or not? In press. It may play a significant role in many health concerns, including cardiovascular disease, diabetes, cancer, osteoporosis, liver disease, cataracts, and male infertility. At GacLife, we are actively working on taking these vital elements and turning them into beverages and powders that can be consumed to receive all the things we need to stay ahead of these major health concerns. Pregnancy rates, while higher for the surgical group, was not statistically different in both groups. (See What It Does). . However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility. Antioxidants such as carotenoids function against free radical damages. In an infertile male with oligospermia or azoospermia with low ejaculate volume, normal secondary sex characteristics, testes and normal hormonal profiles, ejaculatory duct obstruction is suggested. Check out our range of products today and find what works best for you. Male infertility is most often caused by poor sperm motility, quantity, and genetic quality. Early research shows that taking lycopene by mouth daily for 3 months improves sperm quality in some men with fertility problems due to unknown causes. (See What It Does). The leading cause of male infertility stems from a loss of spermatozoa function, ultimately resulting in a loss of fertilization potential . Unfortunately, 30 - 50% of the etiologies of male infertility are unknown and therefore, no specific therapy can be instituted. Moreover, tissue levels of lycopene appear to be too low to play a meaningful antioxidant role. Lycopeneboosts the body's natural antioxidant defences and protects against DNA damage thus promotes heart health. Lycopene is able to reduce bad cholesterol, which can lead to heart disease. 3–12 months. However, in the presence of the highest dose of lycopene, both the viability and osmotic-resistance of chilled spermatozoa and the DNA integrity of frozen spermatozoa were similar to those of fresh spermatozoa. Greater lipid peroxidation was detected in refrigerated compared to fresh or cryopreserved spermatozoa. Lycopene (molecular formula: C40H56) is a linear, unsaturated hydrocarbon carotenoid, the major bright red pigment, a phytochemical found in fruits such as tomatoes and other red fruits such as papaya, pink grapefruit, apricots, red oranges, watermelon, rosehips and guavas 3).Lycopene is the most common carotenoid in the human body and is one of the most potent … In this review, we summarize and evaluate the most important and most recent information pertaining to the use of different medications in male infertility and assign level of evidence to these medications. Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene daily for 3-12 months. Maximum improvement seems to occur in the sperm concentration (66% cases). Male factors, including decreased semen quality, are responsible for ~25% of cases of infertility (Evers, 2002; Sharlip et al., 2002) and, in the USA, the prevalence of men seeking help for fertility is estimated at 3.3–4.7 million (Anderson et al., 2009). Catalase The results showed that there was an improvement in all the spermogram parameters in both groups. The top sources for lycopene include: Gac (70 times more lycopene than any other fruit or vegetable) There is a lack of studies investigating the effects of SOD oral supplementation on human sperm. In over a third of these couples, male infertility plays a role.Male infertility is due to low sperm production, abnormal sperm function or blockages that prevent the delivery of sperm. However, the most common therapeutic scheme suggested consists of an oral dosage of 150 UI a day for at least three months . 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